The Neuropathy Research Group at Kids Neuroscience Centre comprises clinician-researchers and scientists aiming to improve the lives of children with Charcot-Marie-Tooth disease (CMT) by identifying validated scales to measure the disability caused by CMT, effective rehabilitative measures including exercise and orthoses, novel genetic causes of CMT, and disease-modifying therapies through clinical trials.

CMT, otherwise referred to as an inherited peripheral neuropathy, is a common genetic disorder of the motor and sensory nerves. Symptoms first occur in childhood, and nerve degeneration results in weakness of the muscles of the hands and feet and loss of sensation.

While there is currently no curative therapy for CMT, a number of promising compounds have been identified and human trials are either underway or slated to begin.

At The Children’s Hospital at Westmead, children with CMT are evaluated at the Peripheral Neuropathy Management Clinic (PNMC) which includes neurologists, allied health professionals, orthopaedic surgeons, rehabilitation paediatricians and research staff who are experts in CMT.

The PNMC has been identified as an international centre of excellence by the Charcot-Marie-Tooth Association of USA.

Paediatric Gait Analysis Laboratory

The Paediatric Gait Analysis Laboratory is a large clinical research space where clinicians and researchers can assess the function and physical capacity of children who are participating in research projects and clinic trials. Find out more.

The Neuropathy group is jointly led by Dr Manoj Menezes and Prof Joshua Burns and includes a number of key people.

Did you know?

The CMT Paediatric Scale, developed by Prof Joshua Burns, is now the worldwide standard for measuring disease progression in the clinic and clinical trials in children with Charcot-Marie-Tooth disease.

Photo of a child's walking being assessed